John Bruning
Dr Bruning heads the Laboratory of Protein Crystallography, University of Adelaide with research interests in nuclear receptors (NRs), microbial enzymology, and broad-based cancer therapeutics. His work focuses on protein interactions on an atomic level and the structure-function relationships in protein sensor modulation that underpin human disease. His research in NR signalling has uncovered new paradigms in NR allosteric modulations that can be harnessed to employ structure guided drug design. Work in the tuberculosis structural biology consortium has led to a quantum leap in understanding enzymology of the pathogen allowing for new chemotherapy development. Dr Bruning is using similar methodology to study a fungal pathogen for the discovery of new anti-fungal molecules. His research with proteins of the human replication fork, such as PCNA (Proliferating Cellular Nuclear Antigen) has uncovered atomic determinants of these protein modulators that can be used as new paradigms for cancer therapeutic targeting.
Abstracts this author is presenting: